| Decheng Capital LLC | 3,917,299 | 17.9% | +0 |
| CITADEL ADVISORS LLC | 1,283,166 | 5.9% | +40,389 |
| Laurion Capital Management LP | 1,034,459 | 4.7% | +0 |
| VANGUARD CAPITAL MANAGEMENT LLC | 562,877 | 2.6% | +8,776 |
| AQR CAPITAL MANAGEMENT LLC | 480,249 | 2.2% | +345,754 |
| EcoR1 Capital, LLC | 396,194 | 1.8% | — |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 1.4% | +0 |
| BlackRock, Inc. | 187,045 | 0.9% | −605,526 |
| GEODE CAPITAL MANAGEMENT, LLC | 149,844 | 0.7% | −159,605 |
| CANTOR FITZGERALD, L. P. | 116,582 | 0.5% | +49,900 |
| TWO SIGMA INVESTMENTS, LP | 108,377 | 0.5% | −54,978 |
| RAYMOND JAMES FINANCIAL INC | 79,284 | 0.4% | +68,394 |
| VANGUARD FIDUCIARY TRUST CO | 75,172 | 0.3% | −8,038 |
| Woodline Partners LP | 72,429 | 0.3% | +0 |
| MILLENNIUM MANAGEMENT LLC | 69,948 | 0.3% | −28,386 |
