| Thu, 6 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | M-Exempt | 14,292 | $254.97K |
| Thu, 6 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 5,000 | $145K |
| Thu, 6 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 9,292 | $272.6K |
| Thu, 6 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 9,292 | $272.6K |
| Thu, 6 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 5,000 | $145K |
| Thu, 6 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | M-Exempt | 14,292 | $254.97K |
| Wed, 5 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | M-Exempt | 5,849 | $104.35K |
| Wed, 5 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 5,849 | $169.64K |
| Wed, 5 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 5,849 | $169.64K |
| Wed, 5 Aug 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | M-Exempt | 5,849 | $104.35K |
| Thu, 30 Jul 2026 | Thompson Elizabeth H.Z. | officer: EVP, Head of Research & Dev | S-Sale | 50 | $1.31K |
| Thu, 30 Jul 2026 | Thompson Elizabeth H.Z. | officer: EVP, Head of Research & Dev | S-Sale | 16,508 | $431.35K |
| Wed, 29 Jul 2026 | Thompson Elizabeth H.Z. | officer: EVP, Head of Research & Dev | M-Exempt | 32,272 | — |
| Fri, 26 Jun 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | S-Sale | 11,421 | $297.86K |
| Fri, 29 May 2026 | Baker Brothers Life Sciences LP | director, 10 percent owner | A-Award | 18,622 | $0 |
| Fri, 29 May 2026 | Brege Laura | director | M-Exempt | 8,107 | — |
| Fri, 29 May 2026 | Daly James M | director | M-Exempt | 8,107 | — |
| Fri, 29 May 2026 | Poole Jonathan | director | M-Exempt | 2,010 | — |
| Fri, 29 May 2026 | GAROFALO ELIZABETH A. | director | M-Exempt | 8,107 | — |
| Fri, 29 May 2026 | Ndu Adora | director | M-Exempt | 8,107 | — |
| Fri, 29 May 2026 | HARRIGAN EDMUND | director | M-Exempt | 8,107 | — |
| Tue, 26 May 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | S-Sale | 5,401 | $114.39K |
| Mon, 4 May 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | S-Sale | 1,332 | $29.02K |
| Mon, 4 May 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 3,506 | $76.4K |
| Fri, 1 May 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | M-Exempt | 2,596 | — |
| Fri, 1 May 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | M-Exempt | 6,815 | — |
| Tue, 7 Apr 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | S-Sale | 1,030 | $22.87K |
| Tue, 7 Apr 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 2,709 | $60.14K |
| Sun, 5 Apr 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | M-Exempt | 2,010 | — |
| Sun, 5 Apr 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | M-Exempt | 5,276 | — |
| Thu, 26 Mar 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | S-Sale | 12 | $260.76 |
| Thu, 26 Mar 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | S-Sale | 1,097 | $23.75K |
| Thu, 26 Mar 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 37 | $803.64 |
| Thu, 26 Mar 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 3,171 | $68.65K |
| Wed, 25 Mar 2026 | Rhodes Jennifer J | officer: EVP, CHIEF LEGAL OFFICER, SEC | S-Sale | 3,844 | $82.53K |
| Wed, 25 Mar 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | M-Exempt | 2,142 | — |
| Wed, 25 Mar 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | S-Sale | 833 | $17.88K |
| Wed, 25 Mar 2026 | Owen Adams Catherine | director, officer: Chief Executive Officer | S-Sale | 11,641 | $249.93K |
| Wed, 25 Mar 2026 | Thompson Elizabeth H.Z. | officer: EVP, Head of Research & Dev | S-Sale | 3,435 | $73.75K |
| Wed, 25 Mar 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 4,177 | $89.68K |
| Wed, 25 Mar 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | M-Exempt | 6,178 | — |
| Tue, 24 Mar 2026 | Rhodes Jennifer J | officer: EVP, CHIEF LEGAL OFFICER, SEC | M-Exempt | 7,515 | $0 |
| Tue, 24 Mar 2026 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | M-Exempt | 1,627 | — |
| Tue, 24 Mar 2026 | Owen Adams Catherine | director, officer: Chief Executive Officer | M-Exempt | 23,509 | $0 |
| Tue, 24 Mar 2026 | Thompson Elizabeth H.Z. | officer: EVP, Head of Research & Dev | M-Exempt | 6,715 | — |
| Tue, 24 Mar 2026 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | M-Exempt | 8,138 | — |
| Mon, 9 Feb 2026 | Rhodes Jennifer J | officer: EVP, CHIEF LEGAL OFFICER, SEC | S-Sale | 6,950 | $162.49K |
| Fri, 6 Feb 2026 | Rhodes Jennifer J | officer: EVP, CHIEF LEGAL OFFICER, SEC | M-Exempt | 12,944 | $0 |
| Tue, 18 Nov 2025 | Kihara James | officer: PRINCIPAL ACCOUNTING OFFICER | S-Sale | 4,084 | $96.75K |
| Tue, 18 Nov 2025 | Schneyer Mark C. | officer: EVP, CHIEF FINANCIAL OFFICER | S-Sale | 10,262 | $243.11K |
