| Date | Name | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| Wed, 16 Sep 2026 | Matsuda Masaru | officer: See Remarks | S-Sale | 3,674 | $91.85K |
| Tue, 15 Sep 2026 | Welgus Howard G. | director | S-Sale | 4,730 | $114.37K |
| Tue, 15 Sep 2026 | Welgus Howard G. | director | M-Exempt | 1,019 | $7.65K |
| Tue, 15 Sep 2026 | Welgus Howard G. | director | M-Exempt | 822 | $5.36K |
| Tue, 15 Sep 2026 | Welgus Howard G. | director | M-Exempt | 2,255 | $19.46K |
| Tue, 8 Sep 2026 | Matsuda Masaru | officer: See Remarks | S-Sale | 9,989 | $249.99K |
| Thu, 27 Aug 2026 | Curran Terrie | director | M-Exempt | 27,052 | $233.46K |
| Thu, 27 Aug 2026 | Curran Terrie | director | M-Exempt | 11,148 | $83.72K |
| Thu, 27 Aug 2026 | Curran Terrie | director | S-Sale | 27,052 | $677.1K |
| Thu, 27 Aug 2026 | Curran Terrie | director | S-Sale | 11,148 | $279.03K |
| Thu, 20 Aug 2026 | Curran Terrie | director | M-Exempt | 1,072 | $8.05K |
| Thu, 20 Aug 2026 | Curran Terrie | director | S-Sale | 1,072 | $27.91K |
| Wed, 19 Aug 2026 | Burnett Patrick | officer: See Remarks | S-Sale | 1,697 | $45.82K |
| Mon, 17 Aug 2026 | Welgus Howard G. | director | M-Exempt | 1,019 | $7.65K |
| Mon, 17 Aug 2026 | Welgus Howard G. | director | M-Exempt | 2,255 | $19.46K |
| Mon, 17 Aug 2026 | Welgus Howard G. | director | M-Exempt | 1,019 | $7.65K |
| Mon, 17 Aug 2026 | Welgus Howard G. | director | M-Exempt | 822 | $5.36K |
| Mon, 17 Aug 2026 | Welgus Howard G. | director | M-Exempt | 2,255 | $19.46K |
| Mon, 17 Aug 2026 | Welgus Howard G. | director | S-Sale | 4,730 | $123.83K |
| Mon, 17 Aug 2026 | Welgus Howard G. | director | M-Exempt | 822 | $5.36K |
| Mon, 17 Aug 2026 | Welgus Howard G. | director | S-Sale | 4,730 | $123.83K |
| Wed, 12 Aug 2026 | Burnett Patrick | officer: See Remarks | S-Sale | 6,700 | $174.77K |
| Tue, 11 Aug 2026 | Burnett Patrick | officer: See Remarks | M-Exempt | 8,300 | $30.21K |
| Wed, 12 Aug 2026 | Burnett Patrick | officer: See Remarks | M-Exempt | 6,700 | $24.39K |
| Tue, 11 Aug 2026 | Burnett Patrick | officer: See Remarks | S-Sale | 8,300 | $220.13K |
| Tue, 11 Aug 2026 | Burnett Patrick | officer: See Remarks | M-Exempt | 8,300 | $30.21K |
| Wed, 12 Aug 2026 | Burnett Patrick | officer: See Remarks | M-Exempt | 6,700 | $24.39K |
| Tue, 11 Aug 2026 | Burnett Patrick | officer: See Remarks | S-Sale | 8,300 | $220.13K |
| Wed, 12 Aug 2026 | Burnett Patrick | officer: See Remarks | S-Sale | 6,700 | $174.77K |
| Mon, 3 Aug 2026 | Matsuda Masaru | officer: See Remarks | S-Sale | 1,230 | $32.12K |
| Mon, 3 Aug 2026 | Watanabe Todd | director, officer: See Remarks | S-Sale | 4,375 | $114.26K |
| Mon, 3 Aug 2026 | Burnett Patrick | officer: See Remarks | S-Sale | 955 | $24.94K |
| Mon, 3 Aug 2026 | Watanabe Todd | director, officer: See Remarks | S-Sale | 4,375 | $114.26K |
| Mon, 3 Aug 2026 | Burnett Patrick | officer: See Remarks | S-Sale | 955 | $24.94K |
| Mon, 3 Aug 2026 | Matsuda Masaru | officer: See Remarks | S-Sale | 1,230 | $32.12K |
| Wed, 15 Jul 2026 | Welgus Howard G. | director | M-Exempt | 2,255 | $19.46K |
| Wed, 15 Jul 2026 | Welgus Howard G. | director | S-Sale | 4,730 | $127.28K |
| Wed, 15 Jul 2026 | Peetz Christopher | director | A-Award | 4,315 | $0 |
| Wed, 15 Jul 2026 | Welgus Howard G. | director | M-Exempt | 822 | $5.36K |
| Wed, 15 Jul 2026 | Welgus Howard G. | director | M-Exempt | 1,019 | $7.65K |
| Mon, 15 Jun 2026 | Welgus Howard G. | director | M-Exempt | 2,255 | $19.46K |
| Mon, 15 Jun 2026 | Welgus Howard G. | director | M-Exempt | 822 | $5.36K |
| Mon, 15 Jun 2026 | Welgus Howard G. | director | M-Exempt | 1,019 | $7.65K |
| Mon, 15 Jun 2026 | Welgus Howard G. | director | S-Sale | 4,096 | $99.98K |
| Wed, 17 Jun 2026 | Welgus Howard G. | director | S-Sale | 635 | $16.3K |
| Mon, 15 Jun 2026 | LIN SUE-JEAN | director | S-Sale | 4,946 | $120.58K |
| Fri, 5 Jun 2026 | Curran Terrie | director | A-Award | 5,778 | $0 |
| Fri, 5 Jun 2026 | Munshi Amit | director | A-Award | 5,778 | $0 |
| Fri, 5 Jun 2026 | Gilbert Halley E | director | A-Award | 5,778 | $0 |
| Fri, 5 Jun 2026 | Krishnamohan Neha | director | A-Award | 5,778 | $0 |
| Holder | Shares | % out | Change |
|---|---|---|---|
| MONTANOVA CAPITAL, LLC | 12,437,000 | 9.9% | +110,000 |
| BlackRock, Inc. | 10,545,466 | 8.4% | +1,345,055 |
| Frazier Life Sciences Management, L.P. | 9,874,511 | 7.9% | +0 |
| Rubric Capital Management LP | 8,271,577 | 6.6% | +0 |
| Polar Capital Holdings Plc | 6,606,945 | 5.3% | +940,005 |
| STATE STREET CORP | 5,822,840 | 4.6% | −473,357 |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,988,756 | 4.0% | +117,220 |
| MORGAN STANLEY | 4,451,014 | 3.5% | +232,083 |
| JENNISON ASSOCIATES LLC | 4,219,058 | 3.4% | −761,712 |
| D. E. Shaw & Co., Inc. | 3,949,609 | 3.1% | +1,453,387 |
| UBS Group AG | 3,333,015 | 2.7% | +3,791 |
| BANK OF AMERICA CORP /DE/ | 2,987,431 | 2.4% | +766,142 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,982,446 | 2.4% | −62,860 |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 2,429,005 |
| 1.9% |
| +474,320 |
| ORBIMED ADVISORS LLC | 2,042,000 | 1.6% | — |
