| Date | Name | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| Wed, 21 Jan 2026 | Gerard Michael | officer: General Counsel | P-Purchase | 6,600 | $14.98K |
| Wed, 21 Jan 2026 | Simon Mark | director | P-Purchase | 11,061 | $25.22K |
| Wed, 21 Jan 2026 | Nichtberger Steven | director, officer: President & CEO | P-Purchase | 45,000 | $100.8K |
| Wed, 21 Jan 2026 | Bollard Catherine | director | P-Purchase | 4,405 | $10K |
| Wed, 21 Jan 2026 | Gavel Steve | officer: Chief Commercial Officer | P-Purchase | 22,170 | $50.33K |
| Wed, 21 Jan 2026 | Tomasello Shawn | director | P-Purchase | 22,725 | $50.22K |
| Wed, 21 Jan 2026 | Binder Gwendolyn | officer: President, Science & Tech. | P-Purchase | 11,312 | $24.77K |
| Wed, 21 Jan 2026 | Chang David J. | officer: Chief Medical Officer | P-Purchase | 8,800 | $19.89K |
| Holder | Shares | % out | Change |
|---|---|---|---|
| JENNISON ASSOCIATES LLC | 20,033,730 | 11.8% | +11,063,152 |
| Bain Capital Life Sciences Investors, LLC | 17,241,445 | 10.2% | +7,564,320 |
| BlackRock, Inc. | 10,754,701 | 6.3% | +8,381,698 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9,174,758 | 5.4% | +345,000 |
| STATE STREET CORP | 7,839,305 | 4.6% | +7,369,327 |
| VANGUARD CAPITAL MANAGEMENT LLC | 7,227,018 | 4.3% | +3,198,027 |
| Cormorant Asset Management, LP | 5,000,000 | 2.9% | −500,000 |
| Woodline Partners LP | 4,200,142 | 2.5% | +2,949,900 |
| NORGES BANK | 4,112,401 | 2.4% | — |
| Opaleye Management Inc. | 3,863,800 | 2.3% | +2,483,800 |
| CITADEL ADVISORS LLC | 3,522,112 | 2.1% | — |
| GEODE CAPITAL MANAGEMENT, LLC | 3,459,464 | 2.0% | +2,326,219 |
| FRANKLIN RESOURCES INC | 2,413,937 | 1.4% | — |
| 2,211,825 |
| 1.3% |
| +1,428,605 |
| MILLENNIUM MANAGEMENT LLC | 2,068,491 | 1.2% | −3,834,790 |
