| Date | Name | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| Thu, 30 Jul 2026 | BERMAN DENNIS N | director | M-Exempt | 21,854 | $27.54K |
| Wed, 29 Jul 2026 | RA CAPITAL MANAGEMENT, L.P. | 10 percent owner | J-Other | 18,030,000 | — |
| Wed, 29 Jul 2026 | RA Capital Healthcare Fund LP | 10 percent owner | J-Other | 18,030,000 | — |
| Sat, 21 Feb 2026 | Munshi Amit | director | D-Return | 19,089 | $0 |
| Sat, 21 Feb 2026 | Cabell Christopher | officer: President & Head of R&D | D-Return | 338,282 | $0 |
| Sat, 21 Feb 2026 | Aurentz Vincent | director | D-Return | 255,299 | $0 |
| Fri, 21 Nov 2025 | SANDS FRANK M. | 10 percent owner | P-Purchase | 2,068,965 | $3M |
| Holder | Shares | % out | Change |
|---|---|---|---|
| Sands Capital Alternatives, LLC | 13,018,965 | 9.3% | +0 |
| Soleus Capital Management, L.P. | 10,875,000 | 7.8% | +0 |
| Trails Edge Capital Partners, LP | 9,051,318 | 6.5% | +993,973 |
| Fairmount Funds Management LLC | 8,625,000 | 6.2% | +0 |
| BlackRock, Inc. | 7,768,057 | 5.6% | +1,464,624 |
| ADAR1 Capital Management, LLC | 7,387,205 | 5.3% | +780,633 |
| Blackstone Inc. | 5,938,276 | 4.3% | +0 |
| Siren, L.L.C. | 5,850,000 | 4.2% | +0 |
| Commodore Capital LP | 5,397,488 | 3.9% | +0 |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,935,354 | 3.5% | +484,689 |
| MILLENNIUM MANAGEMENT LLC | 4,028,102 | 2.9% | +1,100,025 |
| Saturn V Capital Management LP | 3,869,056 | 2.8% | +5,611 |
| Kalehua Capital Management LLC | 3,821,890 | 2.7% | +1,149,282 |
| Spruce Street Capital LP |
| 3,581,603 |
| 2.6% |
| +0 |
| Squadron Capital Management LLC | 3,000,000 | 2.1% | −500,000 |
