| FMR LLC | 9,126,877 | 14.4% | +2,041,454 |
| Jupiter Topco LLC | 6,273,262 | 9.9% | — |
| Fairmount Funds Management LLC | 4,553,494 | 7.2% | +0 |
| RA CAPITAL MANAGEMENT, L.P. | 3,671,083 | 5.8% | +0 |
| Venrock Adviser, LLC | 3,220,364 | 5.1% | +0 |
| Bellevue Group AG | 3,057,996 | 4.8% | −443,506 |
| Paradigm Biocapital Advisors LP | 2,857,405 | 4.5% | — |
| BlackRock, Inc. | 2,801,451 | 4.4% | +487,502 |
| FRANKLIN RESOURCES INC | 2,792,080 | 4.4% | — |
| STATE STREET CORP | 2,335,285 | 3.7% | +1,679,595 |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,244,773 | 3.5% | +448,121 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,910,812 | 3.0% | — |
| Polar Capital Holdings Plc | 1,846,982 | 2.9% | — |
| Avidity Partners Management LP | 1,700,708 | 2.7% | +300,000 |
| Remedium Capital Partners, LLC | 1,577,750 | 2.5% | +0 |
