| Wed, 22 Jul 2026 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner | P-Purchase | 47,250 | $1.41M |
| Tue, 21 Jul 2026 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner | P-Purchase | 37,723 | $1.13M |
| Tue, 21 Jul 2026 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner | P-Purchase | 6,504 | $189.72K |
| Tue, 21 Jul 2026 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner | P-Purchase | 21,696 | $606.62K |
| Mon, 20 Jul 2026 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner | P-Purchase | 32,987 | $914.4K |
| Mon, 20 Jul 2026 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner | P-Purchase | 98,433 | $2.67M |
| Thu, 11 Jun 2026 | Levy Guy | 10 percent owner | P-Purchase | 375,000 | $7.5M |
| Thu, 11 Jun 2026 | Soleus Capital Group, LLC | 10 percent owner | P-Purchase | 125,000 | $2.5M |
| Thu, 11 Jun 2026 | Soleus Capital Group, LLC | 10 percent owner | P-Purchase | 375,000 | $7.5M |
| Thu, 11 Jun 2026 | Soleus Capital Group, LLC | 10 percent owner | C-Conversion | 527,070 | $5M |
| Thu, 11 Jun 2026 | Levy Guy | 10 percent owner | C-Conversion | 527,070 | $5M |
| Thu, 11 Jun 2026 | Levy Guy | 10 percent owner | P-Purchase | 125,000 | $2.5M |
| Mon, 15 Jun 2026 | SEBULSKY ALAN | director | P-Purchase | 4,065 | $110.16K |
| Mon, 15 Jun 2026 | SEBULSKY ALAN | director | P-Purchase | 5,000 | $130K |
| Fri, 12 Jun 2026 | SEBULSKY ALAN | director | P-Purchase | 8,435 | $233.4K |
| Thu, 11 Jun 2026 | FITZGERALD EDWARD M | director | C-Conversion | 5,539 | — |
| Thu, 11 Jun 2026 | FITZGERALD EDWARD M | director | C-Conversion | 3,878 | — |
| Thu, 11 Jun 2026 | RA Capital Nexus Fund III, L.P. | director | P-Purchase | 19,728,353 | $394.57M |
| Thu, 11 Jun 2026 | Borisy Alexis | director | C-Conversion | 105,414 | — |
| Thu, 11 Jun 2026 | SEBULSKY ALAN | director | P-Purchase | 12,500 | $250K |
| Thu, 11 Jun 2026 | FITZGERALD EDWARD M | director | C-Conversion | 5,271 | — |
| Thu, 11 Jun 2026 | RA Capital Nexus Fund III, L.P. | director | P-Purchase | 1,460,397 | $29.21M |
| Thu, 11 Jun 2026 | RA Capital Nexus Fund III, L.P. | director | C-Conversion | 6,556,740 | — |
| Thu, 11 Jun 2026 | RA Capital Nexus Fund III, L.P. | director | C-Conversion | 1,187,881 | — |
| Thu, 11 Jun 2026 | Deerfield Mgmt HIF, L.P. | 10 percent owner, other | C-Conversion | 122,990 | — |
| Thu, 11 Jun 2026 | Deerfield Mgmt HIF, L.P. | 10 percent owner, other | C-Conversion | 260,992 | — |
| Thu, 11 Jun 2026 | Deerfield Mgmt HIF, L.P. | 10 percent owner, other | C-Conversion | 407,132 | — |
| Thu, 11 Jun 2026 | Deerfield Mgmt HIF, L.P. | 10 percent owner, other | C-Conversion | 149,238 | — |
