| Segment / region | Type | Fiscal year | Currency | Revenue (millions) | Share of revenue |
|---|---|---|---|---|---|
| UNITED STATES | Region | 2025 | USD | 7,548.6 | 45.9% |
| Non-US | Region | 2025 | USD | 5,445.1 | 33.1% |
| Europe | Region | 2025 | USD | 3,460.3 | 21.0% |
| UNITED STATES | Region | 2024 | USD | 6,684.9 | 60.7% |
| Europe | Region | 2024 | USD | 3,453.9 | 31.3% |
| Other, Non U.S. | Region | 2024 | USD | 881.3 | 8.0% |
| UNITED STATES | Region | 2023 | USD | 6,040.4 | 61.2% |
| Europe | Region | 2023 | USD | 3,109.0 | 31.5% |
| Other, Non U.S. | Region | 2023 | USD | 719.8 | 7.3% |
| UNITED STATES | Region | 2022 | USD | 5,699.3 | 63.8% |
| Europe | Region | 2022 | USD | 2,705.5 | 30.3% |
| Other, Non U.S. | Region | 2022 | USD | 525.9 | 5.9% |
| UNITED STATES | Region | 2021 | USD | 5,287.3 | 69.8% |
| Europe | Region | 2021 | USD | 1,972.9 | 26.1% |
| Other, Non U.S. | Region | 2021 | USD | 313.2 | 4.1% |
| UNITED STATES | Region | 2020 | USD | 4,829.3 | 77.8% |
| Europe | Region | 2020 | USD | 1,126.5 | 18.2% |
| Other, Non U.S. | Region | 2020 | USD | 249.9 | 4.0% |
| TRIKAFTA/KAFTRIO | Product | 2025 | USD | 10,312.7 | 86.2% |
| ALYFTREK | Product | 2025 | USD | 837.8 | 7.0% |
| Manufactured Product, Other | Product | 2025 | USD | 820.1 | 6.9% |
| TRIKAFTA/KAFTRIO | Product | 2024 | USD | 10,238.6 | 92.9% |
| Manufactured Product, Other | Product | 2024 | USD | 781.5 | 7.1% |
| TRIKAFTA/KAFTRIO | Product | 2023 | USD | 8,944.7 | 90.6% |
| KALYDECO | Product | 2023 | USD | 475.5 | 4.8% |
| ORKAMBI | Product | 2023 | USD | 326.0 | 3.3% |
| SYMDEKO/SYMKEVI | Product | 2023 | USD | 123.0 | 1.3% |
| TRIKAFTA/KAFTRIO | Product | 2022 | USD | 7,686.8 | 86.1% |
| KALYDECO | Product | 2022 | USD | 553.2 | 6.2% |
| ORKAMBI | Product | 2022 | USD | 510.7 | 5.7% |
| SYMDEKO/SYMKEVI | Product | 2022 | USD | 180.0 | 2.0% |
| TRIKAFTA/KAFTRIO | Product | 2021 | USD | 5,697.2 | 75.2% |
| ORKAMBI | Product | 2021 | USD | 771.6 | 10.2% |
| KALYDECO | Product | 2021 | USD | 684.2 | 9.0% |
| SYMDEKO/SYMKEVI | Product | 2021 | USD | 420.4 | 5.6% |
| TRIKAFTA/KAFTRIO | Product | 2020 | USD | 3,863.8 | 62.3% |
| ORKAMBI | Product | 2020 | USD | 907.5 | 14.6% |
| KALYDECO | Product | 2020 | USD | 802.9 | 12.9% |
| SYMDEKO/SYMKEVI | Product | 2020 | USD | 628.6 | 10.1% |
Product and geographic breakdowns describe the same revenue from different perspectives and should not be added together.
