| Date | Name | Role | Type | Shares | Value |
|---|---|---|---|---|---|
| Thu, 15 Oct 2026 | Evans John M. | director, officer: CEO | S-Sale | 25,000 | $589.15K |
| Fri, 16 Oct 2026 | Evans John M. | director, officer: CEO | S-Sale | 25,000 | $599.6K |
| Fri, 16 Oct 2026 | Evans John M. | director, officer: CEO | M-Exempt | 25,000 | $25.75K |
| Thu, 15 Oct 2026 | Evans John M. | director, officer: CEO | M-Exempt | 25,000 | $25.75K |
| Thu, 1 Oct 2026 | Cavanagh Bethany J | officer: SVP, Finance and Treasurer | S-Sale | 187 | $4.56K |
| Thu, 24 Sep 2026 | Ciaramella Giuseppe | officer: President | G-Gift | 123,407 | $0 |
| Mon, 27 Jul 2026 | Simon Amy |
| officer: Chief Medical Officer |
| S-Sale |
| 16,667 |
| $429.04K |
| Tue, 30 Jun 2026 | Simon Amy | officer: Chief Medical Officer | S-Sale | 373 | $12.95K |
| Mon, 29 Jun 2026 | Evans John M. | director, officer: CEO | S-Sale | 13,421 | $471.53K |
| Tue, 30 Jun 2026 | Evans John M. | director, officer: CEO | S-Sale | 1,900 | $66.2K |
| Tue, 30 Jun 2026 | Evans John M. | director, officer: CEO | S-Sale | 23,100 | $791.48K |
| Tue, 30 Jun 2026 | Evans John M. | director, officer: CEO | M-Exempt | 25,000 | $25.75K |
| Mon, 29 Jun 2026 | Evans John M. | director, officer: CEO | S-Sale | 11,579 | $415.82K |
| Mon, 29 Jun 2026 | Evans John M. | director, officer: CEO | M-Exempt | 6,337 | $6.53K |
| Mon, 29 Jun 2026 | Evans John M. | director, officer: CEO | M-Exempt | 18,663 | $12.5K |
| Fri, 26 Jun 2026 | FMR LLC | 10 percent owner, other | S-Sale | 251,488 | $8.87M |
| Thu, 25 Jun 2026 | FMR LLC | 10 percent owner, other | S-Sale | 33,372 | $1.17M |
| Wed, 17 Jun 2026 | Ciaramella Giuseppe | officer: President | M-Exempt | 6,505 | $4.36K |
| Wed, 17 Jun 2026 | Ciaramella Giuseppe | officer: President | M-Exempt | 29,000 | $29.87K |
| Wed, 1 Apr 2026 | Ciaramella Giuseppe | officer: President | S-Sale | 11,810 | $290.29K |
| Wed, 1 Apr 2026 | Bellon Christine | officer: Chief Legal Officer | S-Sale | 5,956 | $146.4K |
| Wed, 1 Apr 2026 | Cavanagh Bethany J | officer: SVP, Finance and Treasurer | S-Sale | 3,242 | $79.69K |
| Wed, 1 Apr 2026 | Simon Amy | officer: Chief Medical Officer | S-Sale | 6,700 | $164.69K |
| Wed, 1 Apr 2026 | Evans John M. | director, officer: CEO | S-Sale | 30,078 | $739.32K |
| Tue, 31 Mar 2026 | Emany Sravan Kumar | officer: Chief Financial Officer | A-Award | 31,750 | $0 |
| Tue, 31 Mar 2026 | Cavanagh Bethany J | officer: SVP, Finance and Treasurer | A-Award | 20,000 | $0 |
| Tue, 31 Mar 2026 | Bellon Christine | officer: Chief Legal Officer | A-Award | 20,000 | $0 |
| Tue, 31 Mar 2026 | Ciaramella Giuseppe | officer: President | A-Award | 40,000 | $0 |
| Tue, 31 Mar 2026 | Simon Amy | officer: Chief Medical Officer | A-Award | 31,750 | $0 |
| Mon, 30 Mar 2026 | Evans John M. | director, officer: CEO | S-Sale | 25,000 | $559.25K |
| Tue, 31 Mar 2026 | Evans John M. | director, officer: CEO | A-Award | 90,000 | $0 |
| Tue, 31 Mar 2026 | Evans John M. | director, officer: CEO | S-Sale | 25,000 | $569K |
| Tue, 31 Mar 2026 | Evans John M. | director, officer: CEO | M-Exempt | 25,000 | $16.75K |
| Mon, 30 Mar 2026 | Evans John M. | director, officer: CEO | M-Exempt | 25,000 | $16.75K |
| Tue, 24 Feb 2026 | Ciaramella Giuseppe | officer: President | S-Sale | 35,000 | $1.12M |
| Tue, 24 Feb 2026 | Ciaramella Giuseppe | officer: President | M-Exempt | 35,000 | $595K |
| Fri, 30 Jan 2026 | Evans John M. | director, officer: CEO | M-Exempt | 25,000 | $16.75K |
| Fri, 30 Jan 2026 | Evans John M. | director, officer: CEO | S-Sale | 22,094 | $624.6K |
| Fri, 30 Jan 2026 | Evans John M. | director, officer: CEO | S-Sale | 2,906 | $84.27K |
| Thu, 29 Jan 2026 | Evans John M. | director, officer: CEO | S-Sale | 8,667 | $257.76K |
| Thu, 29 Jan 2026 | Evans John M. | director, officer: CEO | S-Sale | 16,333 | $476.76K |
| Thu, 29 Jan 2026 | Evans John M. | director, officer: CEO | M-Exempt | 5,664 | $3.79K |
| Thu, 29 Jan 2026 | Evans John M. | director, officer: CEO | M-Exempt | 19,336 | $12.96K |
| Thu, 22 Jan 2026 | Bellon Christine | officer: Chief Legal Officer | S-Sale | 1,371 | $46.61K |
| Thu, 22 Jan 2026 | Cavanagh Bethany J | officer: SVP, Finance and Treasurer | S-Sale | 6,198 | $216.93K |
| Tue, 20 Jan 2026 | Cavanagh Bethany J | officer: SVP, Finance and Treasurer | S-Sale | 3,034 | $91.38K |
| Thu, 15 Jan 2026 | Bellon Christine | officer: Chief Legal Officer | S-Sale | 559 | $19.79K |
| Thu, 15 Jan 2026 | Bellon Christine | officer: Chief Legal Officer | S-Sale | 2,111 | $70.97K |
| Thu, 15 Jan 2026 | Bellon Christine | officer: Chief Legal Officer | S-Sale | 15,959 | $554.1K |
| Wed, 31 Dec 2025 | Simon Amy | officer: Chief Medical Officer | A-Award | 12,500 | $0 |
| Holder | Shares | % out | Change |
|---|---|---|---|
| FMR LLC | 12,609,002 | 12.2% | +156,803 |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 10,236,396 | 9.9% | +101,700 |
| ARK Investment Management LLC | 10,234,862 | 9.9% | −1,898,571 |
| BlackRock, Inc. | 8,997,542 | 8.7% | +509,973 |
| STATE STREET CORP | 5,827,122 | 5.6% | +127,857 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,921,259 | 4.8% | +350,462 |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,599,437 | 4.5% | +222,063 |
| ARCH Venture Management, LLC | 4,540,132 | 4.4% | +0 |
| Sumitomo Mitsui Trust Group, Inc. | 3,455,043 | 3.3% | −370,542 |
| Amova Asset Management Americas, Inc. | 3,455,043 | 3.3% | −370,542 |
| Kynam Capital Management, LP | 2,840,792 | 2.8% | −841,393 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,596,963 | 2.5% | +178,371 |
| DIMENSIONAL FUND ADVISORS LP | 2,225,844 | 2.2% | +71,269 |
| MORGAN STANLEY | 1,950,969 | 1.9% | +1,302,705 |
| Contrarius Group Holdings Ltd | 1,614,538 | 1.6% | +1,081,095 |
