| Wed, 7 Oct 2026 | Furcht Leo | director | M-Exempt | 250 | $1.9K |
| Thu, 1 Oct 2026 | GRYSKA DAVID W | director | A-Award | 893 | $0 |
| Fri, 14 Aug 2026 | Laing Lance G. | director, officer: Chief Science Officer | A-Award | 20,000 | $0 |
| Fri, 14 Aug 2026 | Laing Lance G. | director, officer: Chief Science Officer | A-Award | 10,000 | $0 |
| Fri, 14 Aug 2026 | Sullivan Brian F. | director, officer: Chief Executive Officer | A-Award | 80,000 | $0 |
| Fri, 14 Aug 2026 | Sullivan Brian F. | director, officer: Chief Executive Officer | A-Award | 120,000 | $0 |
| Fri, 14 Aug 2026 | Hahne Vicky | officer: Chief Financial Officer | A-Award | 16,000 | $0 |
| Fri, 14 Aug 2026 | Hahne Vicky | officer: Chief Financial Officer | A-Award | 10,000 | $0 |
| Fri, 14 Aug 2026 | Sullivan Brian F. | director, officer: Chief Executive Officer | A-Award | 80,000 | $0 |
| Fri, 14 Aug 2026 | Laing Lance G. | director, officer: Chief Science Officer | A-Award | 20,000 | $0 |
| Fri, 14 Aug 2026 | Hahne Vicky | officer: Chief Financial Officer | A-Award | 16,000 | $0 |
| Tue, 14 Jul 2026 | BAKER BROS. ADVISORS LP | other | S-Sale | 2,838,632 | $290.96M |
| Tue, 14 Jul 2026 | BAKER BROS. ADVISORS LP | other | S-Sale | 261,368 | $26.79M |
| Tue, 14 Jul 2026 | BAKER JULIAN | other | S-Sale | 261,368 | $26.79M |
| Tue, 14 Jul 2026 | BAKER JULIAN | other | S-Sale | 2,838,632 | $290.96M |
| Fri, 5 Jun 2026 | NIGON RICHARD | director | A-Award | 1,530 | $0 |
| Fri, 5 Jun 2026 | Dalvey David | director | A-Award | 1,530 | $0 |
| Fri, 5 Jun 2026 | Buller Richard E | director | A-Award | 1,530 | $0 |
| Fri, 5 Jun 2026 | Furcht Leo | director | A-Award | 1,530 | $0 |
| Fri, 5 Jun 2026 | ROMP CHARLES R | director | A-Award | 1,530 | $0 |
| Fri, 5 Jun 2026 | Murphy Polly A. | director | A-Award | 1,530 | $0 |
| Tue, 2 Jun 2026 | Laing Lance G. | director, officer: Chief Science Officer | M-Exempt | 1,000 | $9.89K |
| Tue, 19 May 2026 | Buller Richard E | director | G-Gift | 1,029 | $0 |
| Mon, 4 May 2026 | Dalvey David | director | S-Sale | 25,000 | $3.52M |
| Mon, 4 May 2026 | Buller Richard E | director | S-Sale | 365 | $52.28K |
| Mon, 4 May 2026 | Buller Richard E | director | S-Sale | 2,825 | $401.26K |
| Mon, 4 May 2026 | Buller Richard E | director | S-Sale | 2,301 | $324.51K |
| Mon, 4 May 2026 | Buller Richard E | director | S-Sale | 1,670 | $233.1K |
| Mon, 4 May 2026 | Buller Richard E | director | S-Sale | 550 | $76.45K |
| Mon, 4 May 2026 | Buller Richard E | director | S-Sale | 1,289 | $176.59K |
| Mon, 4 May 2026 | Buller Richard E | director | M-Exempt | 9,000 | $45.9K |
| Thu, 9 Apr 2026 | NIGON RICHARD | director | G-Gift | 10,000 | $0 |
| Tue, 31 Mar 2026 | Buller Richard E | director | S-Sale | 2,325 | $256.01K |
| Tue, 31 Mar 2026 | Buller Richard E | director | M-Exempt | 3,000 | $15.3K |
| Tue, 31 Mar 2026 | Buller Richard E | director | S-Sale | 675 | $74.81K |
| Wed, 11 Feb 2026 | ROMP CHARLES R | director | A-Award | 215 | $0 |
| Tue, 27 Jan 2026 | Dalvey David | director | S-Sale | 20,000 | $2.4M |
| Mon, 15 Dec 2025 | NIGON RICHARD | director | G-Gift | 19,975 | $0 |
| Fri, 5 Dec 2025 | Buller Richard E | director | S-Sale | 1,510 | $160.12K |
| Fri, 5 Dec 2025 | Buller Richard E | director | M-Exempt | 3,000 | $16.5K |
| Fri, 5 Dec 2025 | Buller Richard E | director | S-Sale | 1,490 | $156.96K |
| Thu, 4 Dec 2025 | Furcht Leo | director | M-Exempt | 250 | $1.9K |
| Tue, 2 Dec 2025 | Buller Richard E | director | G-Gift | 500 | $0 |
| Mon, 1 Dec 2025 | Buller Richard E | director | M-Exempt | 1,100 | $16.31K |
| Mon, 1 Dec 2025 | Buller Richard E | director | S-Sale | 1,100 | $107.94K |
| Fri, 21 Nov 2025 | Dalvey David | director | S-Sale | 15,000 | $1.5M |
| Thu, 20 Nov 2025 | Buller Richard E | director | S-Sale | 3,900 | $377.25K |
| Thu, 20 Nov 2025 | Buller Richard E | director | M-Exempt | 3,900 | $57.84K |
| Wed, 19 Nov 2025 | Buller Richard E | director | G-Gift | 500 | $0 |
